The Resident Evil Requiem Reveal That Has Big Implications for a Resident Evil 5 Remake

The Resident Evil Requiem Reveal That Has Big Implications for a Resident Evil 5 Remake Southeast Asia Home Amazon Deals Pro-tips by Codashop PC PS4 Xbox One Nintendo Mobile Entertainment EsportsMoreSearch Home More About IGN SEAContactAdvertisePressUser AgreementPrivacy PolicyCookie PolicyRSSIGN Southeast Asia is operated under license by Media Prima Digital Sdn Bhd Change Region United States United Kingdom Australia Africa Adria Serbian/Croatian Adria Slovenian Benelux / Dutch Brazil China / 中国 Czechia / Slovakia France Germany Greece / Ελλάδα Hungary India Israel Italy / Italia Japan / 日本 Korea / 한국 Latin America Middle East – English Middle East – الأوسطالشرق Nordic Poland Portugal Southeast Asia Spain / España Turkey / Türkiye world.ign.com Register / Login Register / Login Login Register Resident Evil 5 The Resident Evil Requiem Reveal That Has Big Implications for a Resident Evil 5 Remake Canon evolution. This post might contain affiliation links. If you buy something through this post, the publisher may get a share of the sale. By Carlos Morales  Updated: March 5, 2026, 8:30 p.m. Related reads:MapleStorySEA Celebrates 20th Anniversary With Massive Summer Updates This article contains spoilers for Resident Evil Requiem.Resident Evil Requiem is now in our hands and, as our review makes clear, it’s a massive success. But what’s next for Capcom’s long-running horror series? Resident Evil has settled into a release cadence over the last few years that alternates between new mainline entries and extravagant remakes. With the most recent remake being an overhaul of Leon S. Kennedy’s iconic Spain-set adventure, Resident Evil 4, the next one up on the docket is likely to be Chris Redfield’s co-op odyssey, Resident Evil 5. That would be interesting for many reasons, but to make matters more intriguing, one of Resident Evil Requiem’s third act plot reveals seems to hint at the ways Capcom intends to alter the series’ continuity in a hypothetical remake of the fifth mainline chapter. Let’s take a look at how Requiem may be quietly setting up a lore-altering remake of Resident Evil 5.Big SpencerEven people who have never played a Resident Evil game before have probably at least heard of the Umbrella Corporation, the nefarious pharmaceutical company behind many of the series’ biohazardous events. Who they’re less likely to be familiar with is Oswell E. Spencer, the founder and CEO of Umbrella. Although he’s rarely made direct appearances in the games, Spencer could arguably be considered the overarching antagonist of the entire franchise. The first game took place in his mansion, after all, and the series’ dense web of viruses, monsters, and shady villainous factions almost all tie back to Spencer in one way or another because of his initial work with bioweapons. More like thisOpen Back Headphones: A Sound Experience Like No OtherResident Evil Requiem brings Spencer back in the spotlight, but in an unexpected way that recontextualizes his place in the Resident Evil universe. Where previous lore depicted Spencer as a megalomaniacal oligarch who wanted to remake the world using weaponized viruses, Requiem presents a more human side of this ambitious scientist. Alyssa Ashcroft’s interview with Spencer shows a whole new side of Resident Evil’s villian. | Image credit: CapcomIn the game’s final act, protagonist Grace Ashcroft learns that her mother, reporter Alyssa Ashcroft, interviewed Spencer in his twilight years. As part of their meeting, Spencer explained that he’d been taking care of an orphaned infant – Grace herself – and gave her to Alyssa to raise. He also seemed to express genuine remorse for all the death and destruction he’d caused. Requiem doubles down on this idea with the twist that Elpis, Spencer’s secret final project that the villains have been seeking all game long, is not a new bioweapon like they believed, but in fact an antiviral agent that can cure infections caused by Umbrella’s viruses. In Requiem’s “good” ending, Grace realizes that Spencer wanted to atone for his actions by using Elpis to nullify the bioweapons he once created. She releases the antiviral into the world, and Leon is saved from his T-Virus infection. The scene of Spencer and Alyssa’s conversation is remarkable because it managed to evoke pity and even a bit of sympathy from me for a character who I know is an egotistical madman responsible for numerous atrocities and millions of deaths. That’s the power of strong writing and voice work. But while making Spencer more sympathetic serves a self-contained purpose within Requiem’s story, the idea that he had regrets before his death carries huge implications for the series’ established canon, especially as it relates to Resident Evil 5’s place in the timeline.Flashback AttackSpencer made one of his few in-person appearances in Resident Evil 5, popping up in a flashback cutscene that featured him talking with another recurring series antagonist, Albert Wesker. Spencer is shown as an old man in a wheelchair, barely clinging to life while still espousing his eugenics-minded philosophy. He raves about how he had the “right to be a god,” and reveals to Wesker that he was part of a program designed to create superior beings whom Spencer was to be the master of. Wesker then kills Spencer, saying that he was “arrogant even until the end.” Spencer had previously been “arrogant even until the end”. | Image credit: CapcomThis is Spencer’s canonical death, although this version of him is incongruous with the revelations in Requiem. But that might not be a problem if a Resident Evil 5 remake reworks this scene and Spencer’s role in the plot to fit with his newer, more regretful portrayal.Spencer’s death in Resident Evil 5’s main campaign is merely part of a cutscene, but the sequence became more interactive with the Lost in Nightmares DLC. The expansion sees Chris Redfield and Jill Valentine battle Wesker shortly after he kills Spencer, with you fighting in the very same room he commits the deed in. Should this sequence be recreated and integrated into the main campaign of a potential RE5 remake, Capcom would have the opportunity to rewrite Spencer’s final moments so they line up better with Requiem’s reveals. This could be the first moment in the series’ timeline that our heroes learn of Spencer’s real feelings on his legacy. And with the DLC being one of the only parts of RE5 that mechanically feels akin to the franchise’s classic survival horror gameplay, it’s a prime candidate for a level that could be included in a remake that would, presumably, look to reformat the story to better suit the series’ renewed survival horror ambitions.Capcom has already been fairly liberal with Resident Evil remakes making adjustments to previous continuity.It makes a certain amount of sense for Capcom to do this, because this very scene has alr